Real Madrid left it until the dying moments to score but were finally able to break down a resilient Real Betis.
Jorge Molina stunned the Bernabeu when he opened the scoring on 15 minutes. Karim Benzema equalised for the home side 10 minutes later but Betis but up a brilliant rear guard action to keep Real at 1-1.
After a number of near misses and wasted opportunities, with just minutes remaining new signing Isco scored a brilliant header to hand Carlo Ancelotti's men all three points.
More to follow..
Waiting game: Isco's excellent header came in the 86th minute
Stunned: Jorge Molina opened the scoring for Real Betis in front of a shocked crowd at the Bernabeu
Level: Karim Benzema equalises for Real Madrid
Frustrated: Cristiano Ronaldo went close several times but cut a frustrated figure during the match
Watching on: Carlo Ancelotti saw his team leave it late to win
Wasteful: Real missed a number of chances before getting their goal